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Canker Sores Can Be Caused By Dairy Allergy

Published date: April 2, 2014 | Modified date:
by Dr Stephen Wangen

We’ve seen many different causes of canker sores (apthous ulcers), including many different types of food allergies that cause canker sores. This is a summary of a study from the National Institutes of Health on one cause, dairy allergies.

Study Title:
Good tolerance to goat’s milk in patients with recurrent aphthous ulcers with increased immunoreactivity to cow’s milk proteins.

Authors: Besu I1, Jankovic L, Konic-Ristic A, Damjanovic A, Besu V, Juranic Z.


Recurrent aphthous ulcers (RAU) represent a very common, but poorly understood mucosal disorder. The connection between immunity to cow’s milk proteins (CMP) and oral diseases was noted earlier. The goal of this study was to determine the prevalence of the increased levels of serum antibodies to goat’s milk proteins (GMP), by enzyme-linked immunosorbent assay (ELISA) test, in subjects who have RAU and proven increased immunity to CMP.


Fifty subjects with RAU (36 with proven increased immunity to CMP and 14 without this increased immunity) were included in this research. Levels of serum IgA, IgG, and IgE antibodies to the same quantity of the examined antigens were determined by ELISA. The statistical analysis of data was performed by Wilcoxon rank-sum test and Mann-Whitney test.


The levels of serum antifresh cow’s milk IgA, IgG, and IgE antibodies were significantly higher than the levels of serum antifresh goat’s milk, in subjects with RAU with proven increased immunoreactivity to CMP (P = 0.0003; P < 0.0001; P < 0.0001).

These results indicate that patients with RAU with increased immunity to CMP could consider the use of goat’s milk as the alternative protein source.

See the complete study at

If you suffer from canker sores, we know how painful and frustrating they can be. To solve your canker sores please contact us now at the IBS Treatment Center. We can help you sort out this highly annoying problem so that you can talk and chew without pain or fear.