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IBS Poses Increased Risk for Osteoporosis and Related Fractures

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It’s good to see research in this area. Although it shouldn’t be too surprising, since IBS is essentially an indication that food is not being digested properly and that the malabsorption of nutrients is occurring.

Excerpt from

Patients with IBS are more likely to develop osteoporosis and are at increased risk for osteoporosis-related fractures, according to data presented at the 2012 American College of Gastroenterology Annual Scientific Meeting.

The study included 317,857 emergency department visits for patients with secondary IBS diagnoses, collected from the 2008 Nationwide Emergency Department Sample database, and compared them with controls without IBS.

The presence of and risk for osteoporosis and related fractures within the IBS cohort was evaluated, along with potential predictive factors. Analysis included pathologic wrist, vertebrae and femur fractures and traumatic wrist, vertebrae and hip fractures.

Within the assessed cohort, 17,752 patients had an osteoporosis diagnosis, with concurrent fracture diagnoses in 2,197 cases. Risk for osteoporosis was elevated among patients with IBS (OR=4.28; 95% CI, 4.21-4.35), as was risk for osteoporotic fracture (OR=2.36; 95% CI, 2.26-2.47) compared with controls.

Osteoporosis risk was higher in the IBS cohort regardless of age or sex, but the increase was less pronounced among older patients. Investigators calculated ORs of 4.86 (3.09-7.65) for males and 4.46 (3.78-5.25) for females aged 0 to 40 years; 4.98 (4.31-5.75) for males and 3.55 (3.43-3.68) for females aged 41 to 65 years, and 3.08 (2.81-3.39) for males and 2.79 (2.73-2.84) for females aged 66 and older (95% CI for all).


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