IBS Treatment Center

Seattle, WA

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Studies Explore Probiotics for the Treatment of Irritable Bowel Syndrome

Posted on by IBSTC

This is a great example of the disconnect between scientific studies and general knowledge.

This study looked (supposedly) at all of the relevant studies on probiotics and decided that we need more studies. That is true. But it’s already well accepted that probiotics have a significant role in the function of the digestive system. It’s also known that they can help some people with IBS. However, there are many, many different types of probiotics, and many other variables that affect digestive health. It’s almost impossible to design a study that can take all of this into account, and even if one were designed, it could never get funding.

As a doctor providing cutting edge care for my patients, I don’t wait around for studies to demonstrate what basic biology and clinical experience has already demonstrated.

-Dr. Stephen Wangen of the IBS Treatment Center

Excerpt from National Institutes of Health:

Abstract

Irritable bowel syndrome (IBS) is a chronic condition affecting 3%-25% of the general population. As no curative treatment is available, therapy is aimed at reducing symptoms, often with little success.

Because alteration of the normal intestinal microflora has been observed in IBS, probiotics (beneficial microbes taken to improve health) may be useful in reducing symptoms.

This paper systematically reviews randomized, controlled, blinded trials of probiotics for the treatment of IBS and synthesizes data on efficacy across trials of adequate quality. PubMed, Medline, Google Scholar, NIH registry of clinical trials, metaRegister, and the Cochrane Central Register of Controlled Trials were searched from 1982-2007.

We also conducted secondary searches of reference lists, reviews, commentaries, relevant articles on associated diseases, books and meeting abstracts. Twenty trials with 23 probiotic treatment arms and a total of 1404 subjects met inclusion criteria. Probiotic use was associated with improvement in global IBS symptoms compared to placebo [pooled relative risk (RR pooled) 0.77, 95% confidence interval (95% CI) 0.62-0.94]. Probiotics were also associated with less abdominal pain compared to placebo [RR pooled = 0.78 (0.69-0.88)].

Too few studies reported data on other IBS symptoms or on specific probiotic strains to allow estimation of a pooled RR. While our analyses suggest that probiotic use may be associated with improvement in IBS symptoms compared to placebo, these results should be interpreted with caution, given the methodological limitations of contributing studies.

Probiotics warrant further study as a potential therapy for IBS.

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